1. Install Uniwind and Tailwind CSS: `bun install uniwind tailwindcss`.
2. Create `global.css` with `@import 'tailwindcss';` and `@import 'uniwind';`.
3. Import `global.css` in `App.tsx` or `app/_layout.tsx`.
4. Configure `metro.config.js` with `withUniwindConfig`.
5. Add TypeScript definitions by including `uniwind-types.d.ts` in `tsconfig.json`.
6. Configure Tailwind IntelliSense in VS Code.
7. Test styling by applying Tailwind classes to React Native components.
8. Verify theme setup and custom themes.